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Study of VT30-101 in Subjects with PIK3CA or TEK-related Venous, Lymphatic or Mixed Malformations (VT-30)


This is an open-label, repeat-application, intra-subject, dose escalation (Part 1) followed by a randomized, double-blind, placebo-controlled (Part 2) trial of topical VT30 in subjects with venous, lymphatic or mixed malformations associated with PIK3CA or TEK genetic mutations.

Eligibility Criteria

  • Ages eligible for study: 18 - 60 years old (Part 1); 16 - 60 years old (Part 2)

  • Sexes eligible for study: All 

Detailed inclusion and exclusion criteria as listed on


Principal Investigator
Denise W. Metry, MD
Associate Professor of Dermatology and Pediatrics
Office: 832-822-3720