Jianhua Yang, PhD
Dr. Jianhua Yang’s research focuses on elucidating the molecular mechanisms of the growth, differentiation and metastasis of neuroblastoma, as well as identifying and evaluating target genes for therapeutic intervention using pre-clinical animal models. He also has an interest in the understanding of signaling pathways that positively and negatively regulate activation of NF-kappaB transcription factors. NF-kappaB plays critical roles in inflammation, apoptosis, immunity and cancer. Detailed analysis of signaling pathways governing NF-kappaB activation in cancer cells will increase our understanding of the mechanism of unrestricted growth of tumor and help us to identify novel targets for therapeutic drug development to treat cancer. Specifically, he is working on two areas:
- To dissect the role of several identified potential molecular targets in neuroblastoma development and chemo-resistance;
- To determine the molecular mechanism of protein ubiquitination and phosphorylation in the positive and negative regulation of NF-kappaB activation.