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Professor Debananda Pati is a highly accomplished cancer biologist who is an internationally recognized leader in the field of chromosomal cohesion and separation and its role in carcinogenesis. He has a highly impressive track record not only in basic biology of chromosomal cohesion and separation, but devising novel and innovative approaches to target the cohesin pathway for treating refractory human cancers.
Sr. Staff Scientist
Anil Panigrahi, PhD is a member of the research laboratory of Debananda Pati, PhD.
The cohesin component Rad21 is cleaved during apoptosis, and the resultant C-terminal fragment translocates to the cytoplasm to accelerate the apoptotic response. I am working on purifying and identifying the proteinase that cleaves Rad21 during apoptosis. I am also working on protein-interactors of Rad21 to gain insight into the wider picture of cohesin function. I am interested in cohesin biology, eukaryotic epigenetics and gene regulation.