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Principal Investigator
Research Category
Cancer and Blood Disorders
Phone
832-824-4219
Building
Room
1025.09
Floor
10

Andrew Yee, PhD

The balance between bleeding and clotting must be carefully maintained to ensure proper blood function. The blood clotting protein, von Willebrand factor (VWF), critically contributes to this balance. Functional deficits in VWF can lead to extensive blood loss while overactivity can lead to undesired blood clots that block major blood vessels. The molecular determinants of VWF activity are highly variable. 

Our current research aims to determine the functional consequences of all variations in VWF using novel methodologies that may be applied to other blood clotting factors. The goals of this research are to more accurately predict outcomes in patients with bleeding or clotting disorders and to develop novel therapeutics to prevent hemorrhagic or thrombotic complications.

The balance between bleeding and clotting must be carefully maintained to ensure proper blood function. The blood clotting protein, von Willebrand factor (VWF), critically contributes to this balance. Functional deficits in VWF can lead to extensive blood loss while overactivity can lead to undesired blood clots that block major blood vessels. The molecular determinants of VWF activity are highly variable. 

Our current research aims to determine the functional consequences of all variations in VWF using novel methodologies that may be applied to other blood clotting factors. The goals of this research are to more accurately predict outcomes in patients with bleeding or clotting disorders and to develop novel therapeutics to prevent hemorrhagic or thrombotic complications.