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Clinical Sequencing Evidence-Generating Research (CSER): BASIC3

BASIC3 was one of the initial NIH’s Clinical Sequencing Exploratory Research (CSER) program studies. The project’s goal was to develop the first clinical genomic tests that were used for children diagnosed with cancer which were developed by working with the Human Genome Sequencing Center. We evaluated the best way to integrate genomic sequence data into the care of childhood cancer patients who had been newly diagnosed with solid tumors and brain tumors.

The BASIC3 project also evaluated the response of both physicians and parents to this new area of genomic medicine. The BASIC3 study has resulted in the publication of over twelve different articles in the medical literature. These articles include information for the medical community about approaches to consenting parents for genomic studies, what ethical challenges did parents consider when participating in the study and what parents considered the most useful aspects of participating in genomic testing. In addition, the BASIC3 team published important articles highlighting that approximately 40% of children with cancer undergoing genomic testing had potentially important findings from the analysis of blood and tumor samples.

Related News
Broad genetic testing for childhood cancer patients can pinpoint cancer causes and identify potential treatments (January 28, 2016 - Baylor College of Medicine)