Megan R. Lyle, DO


  • Texas Medical Center

Phone: 956-661-9840
Fax: 956-661-9841

Contact Information

101 W. Expressway 83
McAllen, TX 78503
United States

Research Area

  • Sickle Cell Disease

Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine


School Education Degree Year
University of North Texas Health Science Center-Texas College of Osteopathic Medicine Doctor of Osteopathic Medicine 2012
Baylor University bachelors Bachelor of Arts, Philosophy 2006
Virginia Commonwealth University Health fellowship Pediatric Hematology/Oncology 2018
University of Mississippi Medical Center residency Pediatrics 2015


Dr. Lyle is a born-and-raised Texan, dedicated to serving children affected by blood disorders and cancers, to the families battling with them, and to the communities which support them.  

While Dr. Lyle provides care for children and adolescents with a wide range of pediatric cancers, blood disorders, and vascular anomalies, her special interests include disorders of red blood cells (like sickle cell disease, thalassemias, and hereditary spherocytosis), and disorders of bleeding and clotting (such as hemophilia, von Willebrand disease, platelet disorders, Factor V Leiden, protein C and S deficiency, etc.).

Education an integral part of practicing medicine, as well as an indispensable part of quality and safety improvement. Dr. Lyle actively participates in efforts to constantly improve the patient experience by focusing on team safety and efficiency, in addition to community education and outreach.

Board Certifications
American Board of Pediatrics


Organization Name Role
American Academy of Pediatrics (AAP) Member
American Society of Hematology (ASH) Member
American Society of Pediatric Hematology/Oncology (ASPHO) Member
Children’s Oncology Group (COG) Member
Texas Medical Association Member
Texas Osteopathic Medical Association Member

Research Statement

Dr. Lyle's research interests include sickle cell disease, in particular improving diagnosis and management of acute chest syndrome, a serious complication which can occur in the lungs of patients with sickle cell disease; and medical education, especially collaborative development of interdisciplinary curricula in residency and fellowship programs.