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Texas Medical Center

Cancer and Hematology
Phone: 713-798-1265
Office Phone
(713) 798-1230


One Baylor Plaza, N1030
Houston, TX 77030

Research Laboratory

Margaret Goodell, PhD

Professor, Department of Pediatrics, Section of Hematology/Oncology, Cell and Gene Therapy, Baylor College of Medicine

Professor, Stem Cells and Regenerative Medicine Center (STaR), Baylor College of Medicine

Professor, Department of Molecular and Human Genetics, Baylor College of Medicine

Professor, Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine

Professor, Program in Developmental Biology, Baylor College of Medicine

Vivian L. Smith Chair in Regenerative Medicine, Baylor College of Medicine

Co-Leader, Cancer Cel and Gene Therapy, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine


School Education Degree Year
Harvard Medical School Post-doctoral Fellow 1997
Whitehead Institute, Massachusetts Institute of Technology Post-doctoral Fellow 1996
University of Cambridge, Cambridge, England University Doctor of Philosophy 1991
Imperial College, United Kingdom Bachelors Bachelor of Science 1986
Baylor College of Medicine Fellowship


Organization Name Role
National Academy of Medicine Member

Research Statement

Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.

We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.

Research Interests
Murine and human hematopoietic stem cells
Genetic and epigenetic regulation and development

For more information, visit her profile on or learn more about the Center for Cell and Gene Therapy at



* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.