Lisa C. D'Alessandro, MD

Department or Service


  • Texas Medical Center



Phone: 832-824-3278
Fax: 832-825-9052

Contact Information

6651 Main Street
Legacy Tower, 21st Floor
Houston, TX 77030
United States

Attending Cardiologist

Texas Children's Hospital

Assistant Professor of Pediatrics, Baylor College of Medicine


School Education Degree Year
University of Toronto Pediatric Cardiology 2014
The Children's Hospital of Philadelphia fellowship Pediatric Cardiology 2012
University of Western Ontario residency Pediatrics 2009
Schulich School of Medicine & Denistry - Western Univ. medical school Doctor of Medicine 2005


My research focuses on understanding the molecular underpinnings of congenital heart disease and syndromic heart disease, and the identification of factors that may influence prognosis, using technologies such as next-generation sequencing. I am also interested in non-invasive prenatal genetic testing in the fetal heart population.  I believe that genomics is poised to transform how we care for our cardiac patients and will allow us to individualize care including choice of medications, timing of surgery, type of intervention and identification of potentially related complications before they occur.

My clinical interests include cardiovascular genetics, general inpatient and ambulatory cardiology and echocardiography. I am interested in facilitating multidisciplinary care and access to cutting edge genetic technologies and research for patients with cardiac disorders.


Organization Name Role
American College of Cardiology (2014 to Present) Member
American Heart Association (2011 to Present) Member
American Society of Human Genetics (2014 to Present) Member
Canadian Cardiovascular Society (2010 to Present) Member
Fellow of the Royal College of Physicians and Surgeons of Canada (FRCPC) (2012 to Present) Fellow
Ontario Medical Association/Canadian Medical Association (2001 to Present) Member

Selected Publications

D'Alessandro LCA, Casey B, Siu VM. Situs inversus totalis and a novel ZIC3 mutation in a family with X-linked heterotaxy. Congenital Heart Disease 2013;8(2):E36-40. Epub 2011. PMID: 22171628.

D'Alessandro LCA, Latney BC, Prasuna PC, Goldmuntz E. The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle. American Journal of Medical Genetics Part A 2013;161(4):792-802. PMID: 23427188.

D'Alessandro LCA, Werner P, Xie MH, Hakonarson H, White P, Goldmuntz E. The prevalence of 16p12.1 microdeletion in patients with left-sided lesions. Congenital Heart Disease May 2013 [Epub ahead of print]. PMID: 23682798.

Manase D, D'Alessandro LCA, Manickaraj AK, Al Turki S, Hurles M, Mital S. High Throughput Exome Coverage of Clinically Relevant Cardiac Genes. BMC Medical Genomics 2014;7:67.

D'Alessandro LCA, Al Turki S, Manickaraj AK, Manase D, Mulder BJM, Bergin L, Rosenberg H, Mondal T, Gordon E, Lougheed J, Smythe J, Devriendt, UK10K Consortium, Bhattacharya S, Watkins H, Bentham J, Bowdin S, Hurles M, Mital S. Exome sequencing identifies rare variants in multiple candidate genes in atrioventricular septal defect. Genetics in Medicine, advance online publication 21 May 2015.