Kathleen J. Motil, MD, PhD


  • Texas Medical Center



Gastroenterology, Hepatology and Nutrition

Phone: 832-822-3131
Fax: 832-825-4131

Contact Information

6701 Fannin Street
Suite 1100
Houston, TX 77030
United States
Texas US

Attending Physician

Texas Children's Hospital


School Education Degree Year
Harvard Medical School fellowship Pediatric Gastroenterology 1980
McGill University Faculty of Medicine residency Pediatrics 1976
MCP Hahnemann University School of Medicine medical school Doctor of Medicine 1973


Dr. Motil investigates nutrient metabolism in girls and women with Rett syndrome, a neurodevelopmental disorder caused by a mutation in the MECP2 gene. The broad goal of her research is to understand how nutritional interventions modify growth and body composition outcomes in these individuals. Of particular interest is the natural history of osteopenia and the role of dietary, hormonal, inflammatory, and physical factors in the bone health of girls and women with Rett syndrome. Dr. Motil recently demonstrated that osteopenia is present at an early age and worsens across the life span of girls and women with Rett syndrome. She has shown that the bone mineral content (BMC) and density (BMD) of girls and women with Rett syndrome are associated with dietary calcium, phosphorous, and protein intakes whereas correlations between genotype, ambulatory status, hormone profiles, or inflammatory markers and BMC or BMD are not detected. Dr. Motil recently demonstrated that 20% of girls and women with Rett syndrome have vitamin D deficiency. Her research suggests that bone mineral deficits may be amenable, in part, to dietary modifications. She currently is investigating the influence of dietary calcium supplementation on bone mineral content in prepuberal and post pubertal girls with Rett syndrome.


Organization Name Role
American Academy of Pediatrics Member
American Society for Clinical Nutrition Member
North American Society for Pediatric Gastroenterology, Hepatology, Nutrition Member, Nutrition Committee, Ethics Committee, past Chair Ethics Committee

Selected Publications

Motil KJ, Ellis KJ, Barrish JO, Caeg E, Glaze DG. Bone mineral content and bone mineral density are lower in older than in younger females with Rett syndrome. Pediatric Research 2008; 64:435-439.

Patient & Family Comments