Juan C. Marini, PhD, DVM

Department or Service

Location

  • Texas Medical Center

Assistant Professor of Pediatrics

Baylor College of Medicine

Education

School Education Degree Year
University of Illinois, Urbana, IL postgraduate training 2006
Cornell University, Ithaca, NY PhD Animal Nutrition Minor in International Agriculture 2002
Cornell University, Ithaca, NY postgraduate training 2002
Iowa State University, Ames, IA masters Masters of Science in Animal Nutrition Minor in Statistics 1998
Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina postgraduate education Doctor of Veterinary Medicine 1985

About

Research Interests:

Dr. Marini’s research is focused on urea cycle intermediates and their role in supporting ureagenesis and nitric oxide production. Current studies are aimed at increasing our understanding of how the supply of urea cycle intermediates help overcome reduced enzymatic activity found in urea cycle disorder models. We are also investigating the role of genetic background and interorgan transactions of urea cycle intermediates in ornithine transcarbamylase deficiency murine models. In this hypomorphic model, we have shown that the exogenous supply of ornithine is able to restore ureagenesis and mitigate hyperammonemia in C57 mice. However, due to an increase in endogenous ornithine production, mice of different genetic backgrounds harboring the same mutation do not become hyperammonemic.

We are also investigating the role of arginine and intracellular citrulline recycling in sustaining nitric oxide production during basal conditions and LPS challenge in different mouse models. The combination of mouse genetic models and the determination of metabolite fluxes utilizing minimally invasive techniques offers the possibility to study complex pathways and interorgan transaction at the whole organism level in conscious animals.

Organization

Organization Name Role
Institutional Animal Care and Use Committee (IACUC) Member
Mouse Metabolic Research Unit steering committee (MMRU - CNRF) Member

Selected Publications