George Makedonas, PhD
Department or Service
- Texas Medical Center
Baylor College of Medicine
|McGill University||postgraduate education||Experimental Medicine||2006|
I am passionate about discovering the mechanisms that govern protective T cell responses. My approach is to compose comprehensive human T cell profiles: functional capacity -- first and foremost -- phenotype, activation status, differentiation state, and transcription factor expression levels. Of a post-modern philosophy, I embrace the complexity of the T cell; I strive to understand how all its components function to form a coordinated response. Comparative analyses of profiles between human subjects who are sick vs. healthy, treated vs. untreated, vaccinated vs. placebo/unvaccinated, amidst acute vs. chronic infection, etc… identify the salient immune factors for disease pathogenesis and/or host protection. The fruit of these analyses is vital for innovation in patient immune surveillance, therapeutic strategy, and vaccine design and evaluation.
Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, Orange JS, Betts MR. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. Journal of Immunoogy. 2009 May 1;182(9):5560-9. PubMed PMID: 19380804; PubMed Central PMCID: PMC2714586.