Fong Wilson Lam, MD, FAAP
- Critical Care
Attending Physician, Intensive Care Services
Associate Professor of Pediatrics, Division of Pediatric Critical Care Medicine, Baylor College of Medicine
Core Faculty (Center for Translational Research on Inflammatory Diseases; Michael E. DeBakey Veterans Affairs Medical Center)
Associate Director of Fellowship Research and Education, Pediatric Critical Care Medicine Fellowship Program, Baylor College of Medicine
Phone:
832-826-6230
Fax:
832-825-6229
Languages: English
Get to know Fong Wilson Lam, MD, FAAP
Personal Statement
As an intensivist, I am focused on providing excellent care to the entirety of all patients, and helping families cope with the stress of having an ill child. I treat all patients as how I would like my family members to be treated, with respect and patience. I welcome family members to our rounds in order to participate in their child’s care. I use my clinical experience to help educate future physicians as well as my biomedical research to develop a greater understanding and novel treatments for our sickest children.
Clinical Interests
My clinical interests revolve around the multiple organs affected by liver failure and sepsis, serving as part of the Liver Intensive Care Unit (LICU) team. Our LICU team helps to bridge communication between various subspecialty services and brings innovation to the care of critically ill patients with liver failure and after liver transplantation. In addition to the Liver ICU team, I am part of the Extracorporeal Life Support (ECLS or ECMO) team, helping to care for patients with refractory lung and/or heart failure. My clinical interests also revolves around the education of future ICU physicians in which I have created and run the Core and Applied Physiology Curriculum to teach basic and advanced principles to help medical trainees improve the care for their patients.
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research interests
My research interests are in the complex interplay between neutrophils, platelets, and endothelium and how these interactions mediate inflammation and thrombosis. I have focused my research on platelet-neutrophil-endothelial interactions in order to determine novel mechanisms on how these cells interact in different models of inflammation (sepsis, wound injury, and toxin mediated liver injury and fibrosis). Given the current climate of the SARS-CoV-2 pandemic, research into mechanisms and potential therapies are paramount. Our laboratory is creating and testing novel compounds to prevent attachment and inflammation of current and emerging viruses. Finally, I am collaborating with biomedical engineers at the University of Houston to test novel microfluidic devices for apheresis, with the goal of developing new technologies that will allow this life-saving technology in our smallest infants and children. My laboratory is in the Center for Translation Research on Inflammatory Diseases (CTRID) at the Michael E. DeBakey Veterans Affairs Medical Center, where I actively collaborate with experts in the field of platelet biology, vascular biology, and inflammation.
Lezzar DL, Lam FW, Huerta R, Mukhamedshin A, Lu M, Shevkoplyas SS. A high-throughput microfluidic device based on controlled incremental filtration to enable centrifugation-free, low extracorporeal volume leukapheresis. Sci Rep. 2022 Aug 13;12(1):13798. doi: 10.1038/s41598-022-16748-5. PubMed PMID: 35963876; PubMed Central PMCID: PMC9376077.
Mazer MB, Bulut Y, Brodsky NN, Lam FW, Sturgill JL, Miles SM, Shein SL, Carroll CL, Remy KE. Multisystem Inflammatory Syndrome in Children: Host Immunologic Responses. Pediatr Crit Care Med. 2022 Apr 1;23(4):315-320. doi: 10.1097/PCC.0000000000002897. Epub 2022 Jan 20. PubMed PMID: 35050932; PubMed Central PMCID: PMC9058188.
Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA. The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PLoS One. 2020;15(10):e0240164. doi: 10.1371/journal.pone.0240164. eCollection 2020. PubMed PMID: 33048962; PubMed Central PMCID: PMC7553327.
Gorgis NM, Kennedy C, Lam F, Thompson K, Coss-Bu J, Arikan AA, Nguyen T, Hosek K, Miloh T, Karpen SJ, Penny DJ, Goss J, Desai MS. Clinical Consequences of Cardiomyopathy in Children with Biliary Atresia Requiring Liver Transplantation. Hepatology 2018 Aug 3. doi: 10.1002/hep.30204. [Epub ahead of print] PubMed PMID: 30076624.
Lam FW, Da Q, Guillory B, Cruz MA. Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium. J Immunol. 2018 Mar 1;200(5):1718-1726. doi: 10.4049/jimmunol.1700784. Epub 2018 Jan 15. PubMed PMID: 29335256; PubMed Central PMCID: PMC5821592.
Lam FW, Rumbaut RE. Platelets mediate acetaminophen hepatotoxicity. Blood 2015 Oct 8;126(15):1738-9. doi: 10.1182/blood-2015-07-659516. PubMed PMID: 26450954; PubMed Central PMCID: PMC4600013.
Lam FW, Vijayan KV, Rumbaut RE. Platelets and Their Interactions with Other Immune Cells. Compr Physiol. 2015 Jul 1;5(3):1265-80. doi: 10.1002/cphy.c140074. Review. PubMed PMID: 26140718; PubMed Central PMCID: PMC4510953.
