Fong Wilson Lam, MD
As an intensivist, I am focused on providing excellent care to all patients, and helping families cope with the stress of having an ill child. I treat all patients as how I would like my family members to be treated, with respect and patience. I welcome family members to our rounds in order to participate in their child’s care.
My clinical interests revolve around the multiple organs affected by liver failure and sepsis, serving as part of the Liver Intensive Care Unit (LICU) team. Our LICU team helps to bridge communication between various subspecialty services and brings innovation to the care of critically ill patients with liver failure and after liver transplantation. In addition, I am part of the Extracorporeal Life Support (ECLS or ECMO) team, helping to care for patients with refractory lung and/or heart failure.
My research interests revolve around the interactions between inflammation and clotting (thrombosis). My laboratory is dedicated in studying how our first-line immune cells (the neutrophils) behave in both health and in disease, such as infection or inflammation. I am also interested in how platelets, normally thought of to stop bleeding, also act as immune cells. The interactions between platelets and neutrophils have led us to develop and test potential new therapies in our laboratory to hopefully improve outcomes in critically ill patients.
Goldman J, Desai MS, McClain KL, Tcharmtchi MH, Kennedy CE, Thompson K, Lam F, Bashir DA, Chinn IK, Goldberg BR, Allen CE, Nguyen TC. Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis. Pediatr Crit Care Med 2018 Aug 14. doi: 10.1097/PCC.0000000000001684. [Epub ahead of print] PubMed PMID: 30113519.
Gorgis NM, Kennedy C, Lam F, Thompson K, Coss-Bu J, Arikan AA, Nguyen T, Hosek K, Miloh T, Karpen SJ, Penny DJ, Goss J, Desai MS. Clinical Consequences of Cardiomyopathy in Children with Biliary Atresia Requiring Liver Transplantation. Hepatology 2018 Aug 3. doi: 10.1002/hep.30204. [Epub ahead of print] PubMed PMID: 30076624.
Akcan Arikan A, Srivaths P, Himes RW, Tufan Pekkucuksen N, Lam F, Nguyen T, Miloh T, Braun M, Goss J, Desai MS. Hybrid Extracorporeal Therapies as a Bridge to Pediatric Liver Transplantation. Pediatr Crit Care Med. 2018 Jul;19(7):e342-e349. doi: 10.1097/PCC.0000000000001546. PubMed PMID: 29652753.
Lam FW, Da Q, Guillory B, Cruz MA. Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium. J Immunol. 2018 Mar 1;200(5):1718-1726. doi: 10.4049/jimmunol.1700784. Epub 2018 Jan 15. PubMed PMID: 29335256; PubMed Central PMCID: PMC5821592.
Lam FW, Cruz MA, Parikh K, Rumbaut RE. Histones stimulate von Willebrand factor release in vitro and in vivo. Haematologica 2016 Jul;101(7):e277-9. doi: 10.3324/haematol.2015.140632. Epub 2016 Mar 24. PubMed PMID: 27013650; PubMed Central PMCID: PMC5004471.
Lam FW, Rumbaut RE. Platelets mediate acetaminophen hepatotoxicity. Blood 2015 Oct 8;126(15):1738-9. doi: 10.1182/blood-2015-07-659516. PubMed PMID: 26450954; PubMed Central PMCID: PMC4600013.
Lam FW, Vijayan KV, Rumbaut RE. Platelets and Their Interactions with Other Immune Cells. Compr Physiol. 2015 Jul 1;5(3):1265-80. doi: 10.1002/cphy.c140074. Review. PubMed PMID: 26140718; PubMed Central PMCID: PMC4510953.
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