Cameron Dezfulian, MD
I am board certified in both adult and pediatric critical care medicine and have been on faculty teaching and practicing both specialties since 2008, initially at the University of Miami and for the past decade at the University of Pittsburgh. During this time, I devoted a significant portion of my effort to translational research characterizing brain and heart injury, and evaluating protective therapies against them, after cardiac arrest. This consisted both of lab-based experimentation and two phase 1 and two phase 2 randomized clinical trials. I have been active in education, directing or co-directing fellowship training in cardiovascular physiology, respiratory physiology/mechanical ventilation, journal club/evidence-based medicine, a medical school resuscitation track and an American Heart Association funded undergraduate research program.
Beginning August 2020, I moved to Houston to help launch Texas Children’s Hospital’s unique and innovative adult congenital heart disease intensive care unit. I consider it a privilege and blessing to care for critically ill adults and children in Houston and to help train the next generation of critical care physician leaders.
Adult and Pediatric Cardiac Critical Care
Respiratory failure and mechanical ventilation
Cardiac arrest post-resuscitation care
Nitrite/nitric oxide signaling
Free radical injury and protection
Global ischemia and reperfusion injury
Vitturi DA, Maynard C, Olsufka M, Straub AC, Krehel N, Kudenchuk PJ, Nichol G, Sayre M, Kim F, Dezfulian C. Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest. Redox Biol 2020; 32: 101463.
S. Ramgopal, C. Dezfulian, R.W. Hickey, A.K. Au, S. Venkataraman, R.S.B. Clark, C.M. Horvat, Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit, JAMA Netw Open 2019; e199812.
T. Uray, P.E. Empey, T. Drabek, J.P. Stezoski, K. Janesko-Feldman, T. Jackson, R.H. Garman, F. Kim, P.M. Kochanek, C. Dezfulian, Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest, Nitric Oxide 2019; 93:71-77.
Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL and Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med 2020; 48:e133-e140.
Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C and Bayir H. Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Crit Care Med 2019;47:e292-e300.
Chen N, Callaway CW, Guyette FX, Rittenberger JC, Doshi AA, Dezfulian C, Elmer J; Pittsburgh Post-Cardiac Arrest Service. Arrest etiology among patients resuscitated from cardiac arrest. Resuscitation 2018; 130:33-40.
Uray T, Lamade A, Elmer J, Drabek T, Stezoski JP, Misse A, Janesko-Feldman K, Garman RH, Chen N, Kochanek PM, Dezfulian C and the University of Pittsburgh Post-Cardiac Arrest Service. Phenotyping cardiac arrest: bench and bedside characterization of brain and heart injury based on etiology. Critical Care Medicine 2018; 46(6):e508-e515.
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