Bret Bostwick, MD

Department or Service


  • Texas Medical Center
  • The Woodlands



Phone: 832-822-4280

Contact Information

Texas Children's Hospital - The Woodlands
The Woodlands, TX 77384
United States

Texas Children's Hospital - Main Campus
Houston, TX 77030
United States

Assistant Professor, Department of Molecular and Human Genetics

Baylor College of Medicine


School Education Degree Year
University of Wisconsin - Madison medical school Doctor of Medicine 2011


My clinical practice involves the diagnosis, counseling and management of individuals with rare genetic disorders. I have a passion for the evaluation of complex phenotypes and multi-system disease. I perform inpatient and outpatient medical genetics consultations for Texas Children’s Hospital.

Clinical Interests:

As a clinician-educator, I am involved in teaching medical students, genetic counseling students and medical residents. Revolutionary changes in healthcare are demanding physicians excel in team-based care and complex health systems. The recent wave of personalized medicine, including the use of genome sequencing, requires longitudinal integration of the basic sciences with the clinical sciences. I enjoy the challenge of adapting teaching techniques to meet the needs of this ever-changing healthcare landscape.

Research Interests:

Research efforts are focused on immune system perturbation, including primary immunodeficiency, NK cell deficiency and the genetics of auto-inflammation.  I am a clinician for the Undiagnosed Diseases Network at the BCM Clinical Site.  

Special Interests:

Focal Dermal Hypoplasia (Goltz Syndrome), CDK13-Related Disorder

Selected Publications

Bostwick B, et al. "Phenotypic and molecular characterization of focal dermal hypoplasia in 18 individuals.." Am J Med Genet C Semin Med Genet.. 2016 March Pubmed PMID: 26853229

Bostwick, B et al. "Focal Dermal Hypoplasia.." GeneReviews®. 2016 July 21 Pubmed PMID: 20301712

Fergestad T, Sale H, Bostwick B, et al. "A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels.." Proc Natl Acad Sci U S A. Pubmed PMID: 20212103

Fergestad T, Bostwick B, Ganetzky B.. "Metabolic disruption in Drosophila bang-sensitive seizure mutants.." Genetics. Pubmed PMID: 16648587