Bret Bostwick, MD
Department or Service
- Texas Medical Center
- The Woodlands
Assistant Professor, Department of Molecular and Human Genetics
Baylor College of Medicine
|University of Wisconsin - Madison||medical school||Doctor of Medicine||2011|
My clinical practice involves the diagnosis, counseling and management of individuals with rare genetic disorders. I have a passion for the evaluation of complex phenotypes and multi-system disease. I perform inpatient and outpatient medical genetics consultations for Texas Children’s Hospital.
As a clinician-educator, I am involved in teaching medical students, genetic counseling students and medical residents. Revolutionary changes in healthcare are demanding physicians excel in team-based care and complex health systems. The recent wave of personalized medicine, including the use of genome sequencing, requires longitudinal integration of the basic sciences with the clinical sciences. I enjoy the challenge of adapting teaching techniques to meet the needs of this ever-changing healthcare landscape.
Research efforts are focused on immune system perturbation, including primary immunodeficiency, NK cell deficiency and the genetics of auto-inflammation. I am a clinician for the Undiagnosed Diseases Network at the BCM Clinical Site.
Focal Dermal Hypoplasia (Goltz Syndrome), CDK13-Related Disorder
Bostwick B, et al. "Phenotypic and molecular characterization of focal dermal hypoplasia in 18 individuals.." Am J Med Genet C Semin Med Genet.. 2016 March Pubmed PMID: 26853229
Bostwick, B et al. "Focal Dermal Hypoplasia.." GeneReviews®. 2016 July 21 Pubmed PMID: 20301712
Fergestad T, Sale H, Bostwick B, et al. "A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels.." Proc Natl Acad Sci U S A. Pubmed PMID: 20212103
Fergestad T, Bostwick B, Ganetzky B.. "Metabolic disruption in Drosophila bang-sensitive seizure mutants.." Genetics. Pubmed PMID: 16648587