Alan R. Davis, PhD

Department or Service

Location

  • Texas Medical Center

Research Laboratory

Research Area

  • Cancer
  • Cell and gene therapy

Associate Professor, Department of Pediatrics, Section of Hematology-Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine
Secondary appointment, Department of Orthopedic Surgery, Baylor College of Medicine

Education

School Education Degree Year
Leukemia Society of America / UCLA School of Medicine post-doctoral fellow Department of Microbiology and Immunology 1976
University of California, Los Angeles university Doctor of Philosophy, Molecular Biology 1973
University of California, Los Angeles bachelors Bachelor of Arts, Bacteriology 1968

Research Statement

Dr. Alan Davis’ research interest is in identifying signals that govern recruitment and engraftment of stem cells into bone.

Dr. Davis recently demonstrated that an early adult stem cell for the hematopoietic system also efficiently replenishes osteoblast pools in bone. The lab has also developed an adenovirus-based gene therapy system for the rapid induction of bone formation, and is currently developing this system for both spine fusions and long bone defects.

Additionally, his laboratory serves as part of the Vector Development Laboratory for the Center for Cell and Gene Therapy (CAGT) at Baylor College of Medicine. This laboratory works with investigators within Baylor College of Medicine and throughout the international research community to prepare adenoviral, retroviral, or adeno-associated viral vectors for pre-clinical research. The vector core creates more than 50 new viral vectors and provides services to over 100 different research laboratories annually.

His other interests include: osteoblast stem cell, recruitment, function, differentiation and tissue engineering.

Selected Publications

Awards

2017            Department of Defense, Restorative Transplantation Research Program 
2016            National Institutes of Health R15 grants
2015            Department of Defense, grants on heterotopic ossification
2014            Department of Defense, Panel on Respiratory Diseases
2012            Department of Defense, Laboratory featured as a success example, DOD website (CDMRP) 
2010            Extremity War Injuries V,  American Academy of Orthopedic Surgeons 
2010            Society of Bone and Mineral Metabolism
2010            Department of Defense, Filming of our laboratory and interview for heterotopic ossification
2009            Eric Rodenberg and graduate student, Elizabeth Salisbury received Young Investigator Awards, American Society of Bone and Mineral Research               
2008-2009   Abstract review committee, American Society for Cell and Gene Therapy
2007            Program Committee, American Society for Cell and Gene Therapy
2003            National Institutes of Health Study Section, NIAMS, SCOR grants 
2002-2010   Department of Defense Congressionally Directed Peer Reviewed Medical Research Program
2002-2009   Human Gene Therapy
1999            HIV Vaccine Production, Safety, and Immunogenicity Testing, AIDS  Pre-clinical Review Branch 
1996            Human Gene Therapy, Gene Therapy
1995            Steering Committee, National Gene Vector Laboratory, National Institutes of Health