Research and Patient Care

 Humans have much more bacterial than human cellular and genomic architecture in their bodies.

This area has long been understudied, however, and it is only now that we are realizing the importance of the microbiome to our understanding of health, development and disease.
In one recent paper, some of our researchers wrote:

"Mammals are complex assemblages of mammalian and bacterial cells organized into functional organs, tissues, and cellular communities. Human biology can no longer concern itself only with human cells: Microbiomes at different body sites and functional metagenomics must be considered part of systems biology."
        Pflughoeft KJ, Versalovic J. Human microbiome in health and disease. Annu Rev Pathol. 2012;7:99-122.  

In collaboration with the Bioinformatics Research Laboratory, the Human Genome Sequencing Center and the Alkek Center for Metagenomics and Microbiome Research, the Texas Children’s Microbiome Center is strategically placed to partner with a variety of departments and centers at Texas Children’s Hospital. The Microbiome Center on the 9th floor of Feigin Center provides complete service and support from initial study design and sample collection to final metagenomic analysis. We have collaborated with multiple departments already, to study everything from the respiratory tract of premature infants to the potential relationship between irritable bowel disease and gut microbiota.

Our ongoing projects

Comparative microbial genomics

Exploring and defining the pangenome of Lactobacillus reuteri and the probiotic profiles associated with human-derived clades

Metagenomic studies

Abdominal pain
Comparative genomics of Lactobacillus reuteri
Recurrent inflammatory bowel disease (IBD)
Short gut syndrome
Diet in low-birth-weight infants
Respiratory tract infections
Cystic fibrosis