Paula Marie Hertel, MD

Personal Statement

Dr. Hertel's clinical and research expertise focus on pediatric liver disease.  In her clinic, she cares for infants and children of all ages with liver transplants and with liver diseases including biliary atresia, idiopathic neonatal hepatitis, progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome, fatty liver disease, and a multitude of other rare, and often poorly understood, disorders.  Dr. Hertel oversees several long-term research studies conducted at Texas Children’s that are part of an NIH-funded multicenter human subjects research effort entitled “ChiLDREN”, which was designed to combine the research efforts of major pediatric centers in the U.S. and in Canada to better understand biliary atresia and other pediatric liver diseases.  Within the network, she is currently participating in analysis and publication of findings relating to children with neonatal liver disease of unknown cause and PFIC.

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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Harpavat S, Rajraj R, Finegold MJ, Brandt ML, Hertel PM, et al.  Newborn direct or conjugated bilirubin measurements as a potential screen for biliary atresia.  Journal of Pediatric Gastroenterology & Nutrition 62(6):799-803 (2016).

Mouzaki M, Bass LM, Sokol RJ, Piccoli DA, Quammie C, Loomes KM, Heubi JF, Hertel PM, et al.  Early life predictuve markers of liver disease outcome in an international, multicenter cohort of children with Alagille syndrome.  Liver International 36(5):755-60 (2016).

Zhou S, Hertel PM, Finegold MJ, et al.  Hepatocellular carcinoma associated with tight-junction protein 2 deficiency.  Hepatology 62(6):1914-6 (2015).

Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, et al.  Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia:  the START randomized clinical trial.  JAMA 311 (17):1750-9 (2014).

Hertel PM, Bessard BC, Crawford SE, Estes MK.  Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and non replicating virus-like particles.  Vaccine 31 (48):5778-84 (2013).

Hertel PM, Estes MK.  Rotavirus and biliary atresia:  can causation be proven?  Current Opinion in Gastroenterology 28(1):10-7 (2012).

Hertel PM, Crawford SE, Finegold MJ, Estes MK.  Osteopontin upregulation in rotavirus induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia.  Virology 417(2):281-92 (2011).

Patel NC*, Hertel PM*, Estes MK, et al.  Vaccine-acquired rotaviurs in infants with severe combined immunodeficiency.  New England Journal of  Medicine 362(4)314-9 (2010).  *Equal contribution.